Here is some more good advice from a published writer. This one is on how to submit a manuscript, and it comes by way of a blog called Cute Writing, which I sometimes use. It's a good blog, and the advice is also good. Any writer who has gotten to the point where they think they can submit a manuscript, should read this.
One should look especially carefully at the parts about going over the manuscript and cutting out awkward phrases wherever possible, etc.,, and to be prepared for lots of rejectons(e.g. develop a real thick skin, something I myself am not very good at)
About the only thing that I would add to this good advice is, the writer who submits a manuscript, should research who is and is not an appropriate agent or publisher to submit it to, well before they send it out! Things can change, and change rapidly.
Now back to writing, and taking my own advice. . . .